Department of Biomedical Informatics,
Department of Systems Biology, &
Department of Medicine
Columbia University
622 West 168th St. PH20
New York, NY 10032
212 305 9104


Stanford University, Stanford, CA 2008-2012
Ph.D. in Biomedical Informatics, June 2012
M.S. in Biomedical Informatics, December 2011
Arizona State University, Tempe, AZ 2005-2008
B.S. Summa Cum Laude in Computational Mathematics, May 2008
B.S. Summa Cum Laude in Molecular Biosciences/Biotechnology, May 2008

Professional Experience

Columbia University, New York, NY
Associate Professor of Biomedical Informatics (in the Departments of Biomedical Informatics, Systems Biology, and Medicine) (2019-present)
Herbert Irving Assistant Professor of Biomedical Informatics (in the Departments of Biomedical Informatics, Systems Biology, and Medicine), 2012-2019
Director, Clinical Informatics, Herbert Irving Comprehensive Cancer Center, 2013-present
Co-Director, Bioinformatics, Department of Biomedical Informatics, 2017-present
Director, Clinical Informatics, Institute for Genomic Medicine, 2017-present

Stanford University, Stanford, CA
Department of Energy Office of Science Graduate Fellow in the Biomedical Informatics Training Program, 2008-2012.
Doctoral Advisor: Russ Altman,
Doctoral Committee: Atul Butte, Trevor Hastie, and Phillip Tsao,
Dissertation Title: "Data-driven Detection, Prediction, and Validation of Drug-Drug Interactions."

Professional Society Memberships
American Medical Informatics Association (2011-)
American Society of Human Genetics (2016-)
American Society for Clinical Pharmacology and Therapeutics (2016-)
International Society for Computational Biology (2012-2014)
American Statistical Association (2013-2014)

Peer-Reviewed Publications and Pre-prints

Google Scholar NCBI bibliography

Nicholas P Tatonetti and Noemie Elhadad Fine-scale genetic ancestry as a potential new tool for precision medicine Nature Medicine 2021


Nicholas P Giangreco, Guillaume Lebreton, Susan Restaino, Mary Jane Farr, Emmanuel Zorn, Paolo C Colombo, Jignesh Patel, Ryan Levine, Lauren Truby, Rajesh Kumar Soni, Pascal Leprince, Jon Kobashigawa, Nicholas P Tatonetti*, Barry M Fine* Plasma kallikrein predicts primary graft dysfunction after heart transplant The Journal of Heart and Lung Transplantation 2021

Theresa A Koleck, Nicholas P Tatonetti, Suzanne Bakken, Shazia Mitha, Morgan M Henderson, Maureen George, Christine Miaskowski, Arlene Smaldone, Maxim Topaz Identifying Symptom Information in Clinical Notes Using Natural Language Processing Nursing research 2020


ER Silver, HQ Truong, S Ostvar, C Hur, and NP Tatonetti, Association of Neighborhood Deprivation Index With Success in Cancer Care Crowdfunding JAMA network open 3 (12), e2026946-e2026946 (2020)


V Ramlall, J Zucker, and NP Tatonetti, Melatonin is significantly associated with survival of intubated COVID-19 patients medRxiv 2020

DJ Butler, CMozsary, C Meydan, DC Danko, J Foox, ..., Michael Zeitz, Vijendra Ramlall, Undina Gisladottir, ... NP Tatonetti, M Imielinski, H Rennert, C Mason, Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Nature Communications 2020 (In Press)


M Zietz and NP Tatonetti, Associations between blood type and COVID-19 infection, intubation, and death Nature Communications 2020 11 (1), 1-6


P Chandak and NP Tatonetti, Using Machine Learning to Identify Adverse Drug Effects Posing Increased Risk to Women Patterns 2020 1 (7), 100108


Vijendra Ramlall, Phyllis M Thangaraj, Cem Meydan, Jonathan Foox, Daniel Butler, Jacob Kim, Ben May, Jessica K De Freitas, Benjamin S Glicksberg, Christopher E Mason, Nicholas P Tatonetti, Sagi D Shapira Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection Nature Medicine 2020;10.1038/s41591-020-1021-2. doi:10.1038/s41591-020-1021-2


N Giangreco, JE Elias, and NP Tatonetti, No population left behind: improving pediatric drug safety using informatics and systems biology British Journal of Clinical Pharmacology 2020


S Ostvar, H Troung, ER Silver, CJ Lightdale, C Hur, and NP Tatonetti, Transfer learning from simulations improves the classification of OCT images of glandular epithelia bioRxiv 2020

A Krigel, NP Tatonetti, AI Neugut, B Lebwohl No Increased Risk of Colorectal Adenomas in Spouses of Patients with Colorectal Neoplasia Clinical Gastroenterology and Hepatology 18 (2), 509-510

SE Brenner, ML Bulyk, DC Crawford, AA Morgan, P Radivojac, NP Tatonetti, Precision Medicine: Addressing the Challenges of Sharing, Analysis, and Privacy at Scale Pacific Symposium on Biocomputing (2020) 25, 547-550


PM Thangaraj, N Tatonetti Medical data and machine learning improve power of stroke genome-wide association studies. BioRxiv (In preparation)

BS Glicksberg, B Oskotsky, PM Thangaraj, N Giangreco, MA Badgeley, KW Johnson, D Datta, VA Rudrapatna, N Rappoport, MM Shervey, R Miotto, TC Goldstein, E Rutenberg, R Frazier, N Lee, S Israni, R Larsen, B Percha, Li Li, JT Dudley, NP Tatonetti, AJ Butte PatientExploreR: an extensible application for dynamic visualization of patient clinical history from electronic health records in the OMOP common data model Bioinformatics 35 (21), 4515-4518

O Lyudovyk, Y Shen, NP Tatonetti, SJ Hsiao, MM Mansukhani, C Weng Pathway analysis of genomic pathology tests for prognostic cancer subtyping Journal of biomedical informatics 98, 103286

BD De Oliveira, K Xu, TH Shen, M Callahan, K Kiryluk, VD D’Agati, NP Tatonetti, J Barasch, P Devarajan Molecular nephrology: types of acute tubular injury Trends in pharmacological sciences


AO Basile, A Yahi, N Tatonetti Artificial intelligence for drug toxicity and safety Trends in pharmacological sciences

FCG Polubriaginof, P Ryan, H Salmasian, AW Shapiro, A Perotte, Monika M Safford, G Hripcsak, S Smith, NP Tatonetti, DK Vawdrey Challenges with quality of race and ethnicity data in observational databases JAMIA 26 (8-9), 730-736

SC Ahalt, CG Chute, K Fecho, G Glusman, J Hadlock, CO Taylor, ER Pfaff, PN Robinson, H Solbrig, C Ta, N Tatonetti, C Weng, Biomedical Data Translator Consortium Clinical data: sources and types, regulatory constraints, applications Clinical and translational science 12 (4), 329

MR Boland, NP Tatonetti Attention Deficit-Hyperactivity Disorder and Month of School Enrollment NEJM 380(7): 692-693, Feb 2019.


V Ramlall, KM Quinnies, R Vanguri, T Lorberbaum, DB Goldstein, N Tatonetti Predicting the genetic ancestry of 2.6 million New York City patients using clinical data BioRxiv768440 (In revision)


Z Liu, N Tatonetti Familial relationships in electronic health records (EHR) v2 BioRxiv731976


JD Romano, H Li, R Realubit, C Karan, NP Tatonetti Discovering therapeutic activities from venoms using differential gene expression BioRxiv699280 (In preparation)


NP Giangreco, B Fine, NP Tatonetti cohorts: A Python package for clinical ‘omics data management BioRxiv626051


P Thangaraj, B Kummer, T Lorberbaum, M Elkind, N Tatonetti Comparative analysis of EHR-based stroke phenotyping methods, their applications, and interpretation BioRxiv565671 (In preparation)

A Krigel, NP Tatonetti, AI Neugut, B Lebwohl No Increased Risk of Colorectal Adenomas in Spouses of Patients with Colorectal Neoplasia Clinical Gastroenterology and Hepatology

AS Faye, F Polubriaginof, PHR Green, DK Vawdrey, N Tatonetti, B Lebwohl Low Rates of Screening for Celiac Disease Among Family Members Clinical Gastroenterology and Hepatology 17 (3), 463-468

BS Glicksberg, B Oskotsky, N Giangreco, PM Thangaraj, V Rudrapatna, D Datta, R Frazier, N Lee, R Larsen, NP Tatonetti, AJ Butte ROMOP: a light-weight R package for interfacing with OMOP-formatted electronic health record data JAMIA Open 2 (1), 10-14


JD Romano, NP Tatonetti Informatics and computational methods in natural product drug discovery: A review and perspectives Frontiers in Genetics 10, 368

F Spagnolo, P Cristofari, NP Tatonetti, LR Ginzburg, DE Dykhuizen Pathogen population structure can explain hospital outbreaks The ISME journal 12 (12), 2835


CN Ta, M Dumontier, G Hripcsak, NP Tatonetti, C Weng Columbia Open Health Data, clinical concept prevalence and co-occurrence from electronic health records Scientific data 5, 180273

K Shameer, MM Perez-Rodriguez, R Bachar, LL, A Johnson, KW Johnson, BS Glicksberg, MR Smith, B Readhead, J Scarpa, J Jebakaran, P Kovatch, S Lim, W Goodman, DL Reich, A Kasarskis, NP Tatonetti, JT Dudley Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data mining BMC medical informatics and decision making 18 (3), 79

E Castillero, ZA Ali, H Akashi, N Giangreco, C Wang, EJ Stöhr, R Ji, X Zhang, N Kheysin, JS Park, S Hegde, S Patel, S Stein, C Cuenca, D Leung, S Homma, NP Tatonetti, VK Topkara, K Takeda, PC Colombo, Y Naka, HL Sweeney, PC Schulze, I George Tissue‐Specific Analysis of Pharmacological Pathways American Journal of Physiology-Heart and Circulatory Physiology (315) 5 H1463-H1476


Y Hao, K Quinnies, R Realubit, C Karan, NP Tatonetti Tissue‐Specific Analysis of Pharmacological Pathways CPT: pharmacometrics & systems pharmacology 7 (7), 453-463


F Polubriaginof, R Vanguri, K Quinnies, G Belbin, A Yahi, H Salmasian, T Lorberbaum, V Nwankwo, L Li, M Shervey, P Glowe, I Ionita-Laza, M Simmerling, G Hripcsak, S Bakken, D Goldstein, K Kiryluk, E Kenny, J Dudley, DK Vawdrey, NP Tatonetti Disease heritability inferred from familial relationships reported in medical records Cell 173 (7), 1692-1704. e11


NP Tatonetti Science as a Culinary Art: How Data Science and Informatics Will Change Knowledge Discovery for Everyone Annual Review of Biomedical Data Science 1, iv-vi

AS Faye, F Polubriaginof, PH Green, DK Vawdrey, N Tatonetti, B Lebwohl Low Rates of Screening for Celiac Disease Among Family Members; Analysis of Algorithm-Identified Familial Relationships Gastroenterology 154 (6), S-674-S-675


MR Boland, F Polubriaginof, NP Tatonetti A machine learning algorithm to classify FDA Category C drugs. Clinical Pharmacology & Therapeutics 103, S10-S10


NP Tatonetti The Next Generation of Drug Safety Science: Coupling Detection, Corroboration, and Validation to Discover Novel Drug Effects and Drug–drug Interactions Clinical Pharmacology & Therapeutics 103 (2), 177-179


A Yahi, R Vanguri, N Elhadad, NP Tatonetti Generative Adversarial Networks for Electronic Health Records: A Framework for Exploring and Evaluating Methods for Predicting Drug-Induced Laboratory Test Trajectories NIPS ML4H 2017

Knowledge Base workgroup of the Observational Health Data Sciences and Informatics (OHDSI) collaborative, Large-scale adverse effects related to treatment evidence standardization (LAERTES): an open scalable system for linking pharmacovigilance evidence sources with clinical data Journal of Biomedical Semantics 8, 1-15; 10.1186/s13326-017-0115-3

N Macesic, F Polubriaginof, NP Tatonetti Machine learning: novel bioinformatics approaches for combating antimicrobial resistance. Current Opinion in Infectious Diseases 2017/9/12


R Moskovitch, F Polubriaginof, A Weiss, P Ryan, N Tatonetti Procedure Prediction from Symbolic Electronic Health Records via Time Intervals Analytics Journal of Biomedical Informatics 2017/8/17

PJ Kennel, A Saha, DA Maldonado, RGivens, DL Brunjes, ECastillero, X Zhang, RJi, A Yahi, I George, DM Mancini, A Koller, B Fine, E Zorn, PC Colombo, N Tatonetti, EI Chen, PC Schulze Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection The Journal of Heart and Lung Transplantation 2017/8/17


NP Tatonetti Translational medicine in the Age of Big Data Briefings in Bioinformatics 2017/10/12


MR Boland, F Polubriaginof, NP Tatonetti Development of A Machine Learning Algorithm to Classify Drugs Of Unknown Fetal Effect Scientific Reports 7 (1), 12839


MR Boland, P Parhi, L Li, R Miotto, R Carroll, U Iqbal, PA Nguyen, M Schuemie, SC You, D Smith, S Mooney, P Ryan, YJ Li, RW Park, J Denny, JT Dudley, G Hripcsak, P Gentine, and NP Tatonetti Uncovering exposures responsible for birth season–disease effects: a global study Journal of the American Medical Informatics Association 2017/9/28


MR Boland, P Parhi, P Gentine, NP Tatonetti Climate classification is an important factor in assessing quality-of-care across hospitals Scientific Reports 7 (1), 4948


R Moskovitch, H Choi, G Hripcsak, N Tatonetti Prognosis of clinical outcomes with temporal patterns and experiences with one class feature selection IEEE/ACM transactions on computational biology and bioinformatics 2017/5/1 14 (3) 555-563


T Lorberbaum, N Tatonetti Reply: Combination Therapy With Ceftriaxone and Lansoprazole, Acquired Long QT Syndrome and Torsades de Pointes Risk Journal of the American College of Cardiology 69 (14), 1877-1878


MR Boland, KJ Karczewski, NP Tatonetti Ten Simple Rules to Enable Multi-site Collaborations through Data Sharing PLOS Computational Biology 13 (1), e1005278; 10.1371/journal.pcbi.1005278

C Deng, MR Lipstein, L Scotto, XO Jirau Serrano, MA Mangone, S Li, J Vendome, Y Hao, X Xu, SX Deng, RB Realubit, NP Tatonetti, C Karan, S Lentzsch, DA Fruman, B Honig, D W Landry, OA O’Connor Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies Blood 129 (1), 88-99; 10.1182/blood-2016-08-731240

LK Xu, P Rosenstiel, N Paragas, C Hinze, X Gao, TH Shen, M Werth, C Forster, R Deng, E Bruck, RW Boles, A Tornato, T Gopal, M Jones, J Konig, J Stauber, V D’Agati, H Erdjument-Bromage, S Saggi, G Wagener, KM Schmidt-Ott, NP Tatonetti, P Tempst, JA Oliver, P Guarnieri, J Barasch Unique transcriptional programs identify subtypes of AKI Journal of the American Society of Nephrology (2016) 10.1681/ASN.2016090974

JM Banda, L Evans, RS Vanguri, NP Tatonetti, PB Ryan, NH Shah A curated and standardized adverse drug event resource to accelerate drug safety research Scientific Data (3) 2016


Lorberbaum T, Sampson KJ, Chang JB, Iyer V, Woosley RL, Kass RS, Tatonetti NP Coupling data mining and laboratory experiments to discover drug interactions causing QT prolongation Journal of the American College of Cardiology 68 (16) 1756-1764; 10.1016/j.jacc.2016.07.761


Hao Y and Tatonetti NP Predicting G Protein-Coupled Recetpor Downstream Signaling by Tissue Expression Bioinformatics Bioinformatics 32 (22), 3435-3443; 10.1093/bioinformatics/btw510

KW Johnson, K Shameer, A Yahi, R Miotto, D Ricks, J Jebakaran, P Kovatch, P Sengupta, DL Reich, A Kasarskis, S Pinney, NP Tatonetti, Joel T Dudley Pharmacological Factors Associated With Congestive Heart Failure Hospital Readmission: A Case-Study Using 15,768 Heart Failure Patients From Two Health Systems Circulation 134 (Suppl 1), A19489-A19489;


Chang JB, Quinnies KM, Realubit R, Karan C, Rand JH, Tatonetti NP A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient Scientific Reports 6/29387 doi:10.1038/srep29387


Moskovitch R, Choi H, Hripcsak G, Tatonetti N, Prognosis of Clinical Outcomes with Temporal Patterns and Experiences with One Class Feature Selection IEEE/ACM Transactions on Computational Biology and Bioinformatics 14 July 2016; 10.1109/TCBB.2016.2591539


Boland MR, Tatonetti NP, Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review. The Pharmacogenomics Journal 12 July 2016; doi: 10.1038/tpj.2016.48

Nissim N, Boland MR, Tatonetti NP, Elovici Y, Hripcsak G, Shahar Y, Moskovitch R, Improving Condition Severity Classification with an Efficient Active Learning Based Framework. J Biomed Inform. 2016 Mar 22. pii: S1532-0464(16)30007-7. doi: 10.1016/j.jbi.2016.03.016

Hoffman KB, Dimbil M, Tatonetti NP, Kyle RF, A Pharmacovigilance Signaling System Based on FDA Regulatory Action and Post-Marketing Adverse Event Reports. Drug Safety 2016 Mar 5


T Lorberbaum, KJ Sampson, RL Woosley, RS Kass, NP Tatonetti, An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval Drug Safety pp 1-9 (2016) doi:10.1007/s40264-016-0393-1

BA Kidd, A Wroblewska, MR Boland, J Agudo, M Merad, NP Tatonetti, BD Brown, JT Dudley Mapping the effects of drugs on the immune system Nature biotechnology 34 (1), 47-54 (2016)

KB Hoffman, M Dimbil, RF Kyle, NP Tatonetti, CB Erdman, A Demakas, D Chen, BM Overstreet A Drug Safety Rating System Based on Postmarketing Costs Associated with Adverse Events and Patient Outcomes Journal of managed care & specialty pharmacy (2015)

C Deng, M Lipstein, L Scotto, Y Hao, NP Tatonetti, M Mangone, S Li Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome 2015 Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas Blood 126 (23), 593-593 2015


JD Romano, NP Tatonetti, VenomKB, a new knowledge base for facilitating the validation of putative venom therapies ScientificData 2 (2015) doi:10.1038/sdata.2015.65


MR Boland, A Jacunski, T Lorberbaum, JD Romano, R Moskovitch, NP Tatonetti Systems biology approaches for identifying adverse drug reactions and elucidating their underlying biological mechanisms WIREs Syst Biol Med. (2015) doi: 10.1002/wsbm.1323


A Jacunski, S Dixon, NP Tatonetti, Connectivity homology enables inter-species network models of synthetic lethality PLOS Computational Biology (2015) 11(10): e1004506. doi:10.1371/journal.pcbi.1004506


MR Boland, Z Shahn, D Madigan, G Hripcsak, NP Tatonetti, Birth Month Affects Lifetime Disease Risk: A Phenome-Wide Method Journal of the American Medical Informatics Association (2015)


S Vilar, T Lorberbaum, G Hripcsak, NP Tatonetti, Improving Detection of Arrhythmia Drug-Drug Interactions in Pharmacovigilance Data through the Implementation of Similarity-Based Modeling PLOS One (2015) 10 (6), e0129974

S Ayvaz, J Horn, O Hassanzadeh, Q Zhu, J Stan, NP Tatonetti, S Vilar, M Brochhausen, M Samwald, M Rastegar-Mojarad, M Dumontier, RD Boyce Toward a complete dataset of drug–drug interaction information from publicly available sources Journal of Biomedical Informatics (2015) 55, 206-217

MR Boland, NP Tatonetti, G Hripcsak, Development and validation of a classification approach for extracting severity automatically from electronic health records Journal of Biomedical Semantics (2015) 6 (1), 14

S Vilar, NP Tatonetti, G Hripcsak, 3D Pharmacophoric Similarity improves Multi Adverse Drug Event Identification in Pharmacovigilance Scientific Reports (2015) 5


T Lorberbaum, M Nasir, MJ Keiser, S Vilar, G Hripcsak, NP Tatonetti Systems pharmacology augments drug safety surveillance Clinical Pharmacology & Therapeutics (2015) 97 (2), 151-158

KB Hoffman, AR Demakas, M Dimbil, NP Tatonetti, CB Erdman Stimulated Reporting: The Impact of US Food and Drug Administration-Issued Alerts on the Adverse Event Reporting System (FAERS) Drug Safety (2014) 37 (11), 971-980


R Moskovitch, C Walsh, G Hripcsak, N Tatonetti Prediction of biomedical events via time intervals mining ACM KDD Workshop on Connected Health in Big Data Era 2014

R D Boyce, P B Ryan, G N Norén, M J Schuemie, C Reich, J Duke, N P Tatonetti, G Trifiro, R Harpaz, J M Overhage, A G Hartzema, M Khayter, E A Voss, C G Lambert, V Huser, M Dumontier Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest Drug Safety 37 (8), 557-567


S Vilar, E Uriarte, L Santana, C Friedman, NP Tatonetti, State of the Art and Development of a New Drug-Drug Interaction Large Scale Predictor Based on 3D Pharmacophoric Similarity Current Drug Metabolism 15 (5), 490-501

S Vilar, PB Ryan, D Madigan, PE Stang, MJ Schuemie, C Friedman, NP Tatonetti, G Hripcsak Similarity‐Based Modeling Applied to Signal Detection in Pharmacovigilance CPT: pharmacometrics & systems pharmacology 3 (9) 1-9 2014


S Vilar, E Uriarte, L Santana, T Lorberbaum, G Hripcsak, C Friedman, NP Tatonetti, Similarity-based modeling in large-scale prediction of drug-drug interactions Nature Protocols (2014 Vol 9 Issue 9, 2147-2168)

MJ Matos, S Vilar, S Kachler, A Fonseca, L Santana, E Uriarte, F Borges, NP Tatonetti, KN Klotz. Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors. ChemMedChem 2014/7/18

Boyce RD, Ryan PB, Norén GN, Schuemie MJ, Reich C, Duke J, Tatonetti NP, Trifirò G, Harpaz R, Overhage JM, Hartzema AG, Khayter M, Voss EA, Lambert CG, Huser V, Dumontier M. Bridging Islands of Information to Establish an Integrated Knowledge Base of Drugs and Health Outcomes of Interest. Drug Safety 2014 Jul 2.

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife 2014 May 20;3:e02523. doi: 10.7554/eLife.02523.

ZA Ali, S Poludasu, YH Qureshi, P Krishnan, AA Ali, N Tatonetti, P Downey, A Zalewski, T Nazif, I George, A Mandava, U Baber, G Dangas, R Mehran, AS Kini, and SK Sharma, Impact of major bleeding on long-term mortality in anemic versus nonanemic patients undergoing percutaneous coronary intervention using bivalirudin, The American journal of cardiology 113, 1481–1486 (2014).

L Li, DJ Ruau, CJ Patel, SC Weber, R Chen, NP Tatonetti, JT Dudley, and AJ Butte, Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records, Science Translational Medicine 6, 234ra57 (2014).

GL Delogu, S Serra, E Quezada, E Uriarte, S Vilar, NP Tatonetti, and D Viña, Monoamine Oxidase (MAO) Inhibitory Activity: 3-Phenylcoumarins versus 4-Hydroxy-3-phenylcoumarins, ChemMedChem (2014), doi:10.1002/cmdc.201402010.

MJ Matos, S Vilar, V Garcia-Morales, NP Tatonetti, E Uriarte, L Santana, D Vina Insight into the Functional and Structural Properties of 3‐Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition. ChemMedChem (2014) Apr 8

KB Hoffman, M Dimbil, CB Erdman, NP Tatonetti, BM Overstreet The Weber Effect and the United States Food and Drug Administration’s Adverse Event Reporting System (FAERS): Analysis of Sixty-Two Drugs Approved from 2006 to 2010. Drug Safety (2014) Vol 37 Iss 4 pp 283-294

MJ Matos, P Janeiro, RM Gonzalez Franco, S Vilar, NP Tatonetti, L Santana, E Uriarte, F Borges, JA Fontenla, D Vina, Synthesis, pharmacological study and docking calculations of new benzo [f] coumarin derivatives as dual inhibitors of enzymatic systems involved in neurodegenerative diseases. Future medicinal chemistry (2014) Vol 6 Iss 4 pp 371-383


KJ Karczewski, M Snyder, RB Altman, NP Tatonetti, Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association. PLOS Genetics (2014) 10(2): e1004122. doi:10.1371/journal.pgen.1004122

KJ Karczewski, GH Fernald, AR Martin, M Snyder, NP Tatonetti, JT Dudley, STORMSeq: An Open-Source, User-Friendly Pipeline for Processing Personal Genomics Data in the Cloud. PLOS One (2014) 9 (1), e84860


X Sun, S Vilar, NP Tatonetti, High-Throughput Methods for Combinatorial Drug Discovery. Science Translational Medicine (2013), 5 (205), 205rv1-205rv1.


A Jacunski, NP Tatonetti, Connecting the Dots: Applications of Network Medicine in Pharmacology and Disease. Clinical Pharmacology & Therapeutics (2013).

MJ Matos, S Vilar, NP Tatonetti, L Santana, E Uriarte, Comparative study of the 3-phenylcoumarin scaffold: synthesis, X-ray structural analysis and semiempirical calculations of a selected series of compounds. Journal of Molecular Structure (2013).

M A Perera, L Cavallari, N Limdi, E Gamazon, A Konkashbaev, R Daneshjou, A Pluzhnikov, D C Crawford, J Wang, N Liu, NP Tatonetti, S Bourgeois, H Takahashi, Y Bradford, B M Burkley, R J Desnick, J L Halperin, S I Khalifa, T Y Langaee, S A Lubitz, E A Nutescu, M Oetjens, M H Shahin, S R Patel, H Sagreiya, M Tector, K E Weck, M J Rieder, S A Scott, A HB Wu, J K Burmester, M Wadelius, P Deloukas, M J Wagner, T Mushiroda, M Kubo, D M Roden, N J Cox, R B Altman, T E Klein, Y Nakamura, J A Johnson, Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. The Lancet (2013).

Ferino G, Cadoni E, Matos MJ, Quezada E, Uriarte E, Santana L, Vilar S, Tatonetti NP, Yanez M, Vina D, Picciau C, Serra S, Delogu G, MAO Inhibitory Activity of 2‐Arylbenzofurans versus 3‐Arylcoumarins: Synthesis, in vitro Study, and Docking Calculations. ChemMedChem (2013).

S Vilar, E Uriarte, L Santana, NP Tatonetti, C Friedman. Detection of Drug-Drug Interactions by Modeling Interaction Profile Fingerprints. PLoS One 8 (3), e58321.

White RW, Tatonetti NP, Shah NH, Altman RB, Horvitz E, Web-scale pharmacovigilance: listening to signals from the crowd. J Am Med Inform Assoc (2013).

Matos MJ, Vilar S, Gonzalez-Franco RM, Uriarte E, Santana L, Friedman C, Tatonetti NP, Viña D, Fontenla JA, Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study. European Journal of Medicinal Chemistry 63, 151-161 (2013).


Tatonetti NP, Denny JC, Altman RB, Response to "Use of an algorithm for identifying hidden drug-drug interactions in adverse event reports" by Gooden et al, J Am Med Inform Assoc (2013), doi:10.1136/amiajnl-2012-001603.

Vilar S, Uriarte E, Santana L, Tatonetti NP, Friedman C, Detection of drug-drug interactions by modeling interaction profile fingerprints. PLoS ONE 8, e58321 (2013).

R Daneshjou, NP Tatonetti, KJ Karczewski, H Sagreiya, S Bourgeois, K Drozda, JK Burmester, T Tsunoda, T Nakamura, M Kubo, M Tector, NA Limdi, KH Cavallari, M Perera, JA Johnson, TE Klein, RB Altman Pathway analysis of genome-wide data improves warfarin dose prediction BMC genomics 14 (Suppl 3) S11 2013


Tatonetti NP, Ye PP, Daneshjou R, Altman RB, Data-driven prediction of drug effects and interactions. Science Translational Medicine 4, 125ra31 (2012).

Karczewski, KJ, Tirrell RP, Cordero P, Tatonetti NP, Dudley JT, Salari K, Snyder M, Altman RB, Kim SK. Interpretome: A freely available, modular, and secure personal genome interpretation engine. Pac Symp Biocomput 17:339-350(2012)

Karczewski, K.J. Tatonetti NP, Landt SG, Yang X, Slifer T, Altman RB, Snyder M. Cooperative transcription factor associations discovered using regulatory variation. Proc Natl Acad Sci USA 108, 13353–13358 (2011).


Tatonetti, N.P., Fernald, G.H. & Altman, R.B. A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports. J Am Med Inform Assoc (2011) DOI:10.1136/amiajnl-2011-000214


Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, P Yue, PS Tsao, Kohane I, Roden DM, and Altman RB. Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels Clinical Pharmacology & Therapeutics 2011 DOI:10.1038/clpt.2011.83


Tatonetti NP*, Dudley JT*, Sagreiya H, Butte AJ, Altman RB. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. BMC Bioinformatics 2010 11(Suppl 9):S9. PMID:21044367


Garten Y*, Tatonetti NP*, Altman RB. Improving the prediction of pharmacogenes using text-derived drug-gene relationships. Pac Symp Biocomput (2010) pp. 305-14. PMID:19908383


Tatonetti NP, Liu T, Altman RB. Predicting drug side-effects by chemical systems biology. Genome Biology (2009) vol. 10 (9) pp. 238, PMID:19723347

* Denotes equal contribution.

FA First Author Publication LA Last Author Publication SA Solo Author Publication

Funding Awarded

Data-driven drug discovery: investigating the molecular mechanisms of safety and efficacy R35 GM131905 National Institute for General Medical Sciences ~$2.5 million (PI: Tatonetti)

Clinical and genomic data mining to study pharmacogenomics of drug-induced liver injury Amgen, Inc. (PI: Tatonetti)

Clinical and genomic data mining to study pharmacogenomics of drug-induced liver injury Amgen, Inc. (PI: Tatonetti)

Biomedical Data Translator Technical Feasibility Assessment and Architecture Design OT3 TR002027 National Center for Advancing Translational Research ~$1.8 million (Contact PI: Tatonetti)

Development of an automated clinical informatics system to facilitate genomic discovery AstraZeneca, Inc (PI: Goldstein, Project Lead: Tatonetti)

Genomics of Non-alocholic fatty liver diseae (NAFLD) Janssen Research & Development, LLC (PI: Wattacheril)

Systems Pharmacology to Predict Adverse Drug Reactions Irving Scholars Program, Irving Institute for Clinical and Translational Research, Columbia University Medical Center. $180,000 (PI: Tatonetti)

Drug Effect Discovery Through Data Mining and Integrative Chemical Biology. R01 GM107145 National Institute for General Medical Sciences. ~$2.5 million (PI: Tatonetti).

Leveraging Big-Data for Drug Discovery in Diseases of Metabolism. PhRMA Foundation Research Starter Award. $100,000 (PI: Tatonetti).

WICER 4 U To develop integrative informatics approaches to investigate genetic determinants of clinical outcomes in a longitudinal electronic health records of a community health center. (PI: Bakken, Pilot-Project PI: Tatonetti)

High-throughput and computational drug screening. CPS Ignition Grant Application (PIs: Ali and Tatonetti)

Novel Statistical Methods for Observational Clinical Studies Innovation awards in population medicine research pilot grant. $25,000. (PI: Altman)

Professional Service

External Advisory Panel, Center for Excellence for Natural Product-Drug Interaction Research, 2020-Present

Member, Editorial Board, Annual Reviews of Biomedical Data Science, 2020-Present

Member, International Scientific Advisor Board, UK Biobank, 2019-Present

Special Member, Editorial Board, Annual Reviews of Biomedical Data Science, 2019

National Institute on Aging (NIA) U19 Review Committee, 2018

Chair, AMIA Summit on Translational Bioinformatics, San Francisco, March 2018

Editorial Board Member, Journal of Biomedical Informatics, 2016-2019

Honorary Editorial Board Member, Drug Safety, 2015-

Vice Chair, AMIA Summit on Translational Bioinformatics, San Francisco, March 2017

Track Chair, AMIA Summit on Translational Bioinformatics, San Francisco, March 2016

Session Chair, Big Data to Knowledge, AMIA Translational Bioinformatics Meeting, San Francisco, March 2015

Session Chair, Big Data to Knowledge, AMIA Translational Bioinformatics Meeting, San Francisco, March 2014

Chair, Pre-conference on Next Generation Pharmacology, ASCPT Annual Meeting, March 2014

Editorial Board Member, Pharmacology Research & Perspectives, 2013-

Scientific Program Committee Member, AMIA Summit on Translational Bioinformatics, 2013, 2014, 2015, 2016

Reviewer: Nature, Science, Cell, NEJM, BMJ, Circulation, Nature Medicine, Science Translational Medicine, Cell Systems, Clinical Pharmacology & Therapeutics, CPT:Pharmacometrics & and Systems Pharmacology, PLOS Genetics, PLOS Comp Bio, PLOS One, Molecular Systems Biology, JAMIA, AMIA Symposium, BMC Bioinformatics, Scientific Reports, Journal of Biomedical Informatics, Drug Safety, Database, Allergy, Pacific Symposium on Biocomputing, Bioinformatics

NIH Peer Reviewer, Special section on Genome-wide Gene by Environment Interactions

Invited Talks and Panels

Invited Speaker, American Society for Human Genetics, Houston, October 15-19, 2019

Keynote Speaker, Health Research Symposium 2019, Hong Kong, June 12, 2019

Invited Speaker, ISPE Mid-Year Meeting 2019, Rome, Italy, April 8, 2019

Keynote Speaker, Onassis Health Day, Athens, Greece, February 11, 2019

Keynote Speaker, World Preclinical Congress Europe, Lisbon, November 25-28, 2018

Keynote Speaker, WCP2018 18th Congress on Basic and Clinical Pharmacology, Kyoto, July 1-6, 2018

Invited Speaer, Big Data for Pharmacovigilance, Drug Safety Research Unit, London, June 20-21, 2018

Invited Speaker, Gordon Research Conference on Drug Safety, Boston, June 10-15, 2018

Keynote Speaker, Molecular Medicine Tri-Conference, February 13th, 2018

Distinguished Lecturer, School of Pharmacy, University at Buffalo, February 1st, 2018

Invited Speaker, AI in Healthcare Summit, Boston, January 19th, 2018

Keynote Speaker, Translational Bioinformatics Conference 2017, San Diegeo, September 29th, 2017

Keynote Lecturer, Ben Gurion University, September 12th, 2017

Invited Speaker, Journalism in Science Conference, Dortmund, Germany, August 7th, 2017

Invited Speaker, AI in Healthcare Summit 2017, San Francisco, July 26th, 2017

Keynote Speaker, Biocomputation at Stanford, 2017, April 10th, 2017

Invited Speaker, ASCPT Annual Meeting 2017, March 18th, 2017

European Medicines Agency, London, November 13th, 2016

Invited Speaker, Future directions in medical data science, London October 10th, 2016

Plenary Speaker, American Society for Human Genetics Annual Meeting 2016, Vancouver, October 18th, 2016

New York Academy of Sciences, New York, September 16th, 2016

Drug Safety Conference, Chicago, June 20th, 2016

Department of Biomedical Informatics, Harvard University, Boston, April 6th, 2016

Five Points Lecture, New York Genome Center, New York City, February 3rd, 2016

New York City Genome Data, Rockefeller University, New York City, January 13th, 2016

Department of Biostatistics and Medical Informatics, UW Madison, Madison, December 11th, 2015

Albany College of Pharmacy and Health Sciences, Albany, October 30th, 2015

World Drug Safety Conference, Chicaco, October 27th, 2015

NHLBI Lecture Series, Washington, D.C., October 13th, 2015

Basel Life Sciences Week, Switzerland, September 23rd, 2015

Big Data and Clinical Trials Conference, Philadelphia, August 25th, 2015

Center for Cancer Systems Biology Seminar Series, Stanford University, Stanford, June 19th, 2015

John Jones Surgical Socieity Annual Meeting, Columbia University, May 8th, 2015

Drug Safety Conference, Chicago, April 22th, 2015

Lecture at Mount Sinai Icahn School of Medicine, New York City, December 19th, 2014

Kavli Foundation Symposium, Indonesia, June 19th, 2014

American Diabetes Association Annual Meeting, Section on Data Science, June 17, 2014

IBM Watson Research Center, Seminar Series, June 4, 2014

Cornell University Medical Center, Seminar Series, June 11, 2014

Uppsala Monitoring Centre Research Conference 2014, Risk: Whose Risk? What Risk?, May 2014

ASPET Annual Conference, Session on Data Science, April 2014

University of California, San Francisco, Pharmaceutical Sciences and Pharmacogenomics Seminar Series, February 10, 2014

Joint Statistical Meetings, Montreal, Canada, August 2013.

Food and Drug Administration meeting on Social Medial Data, Washington, DC, September 2013.

Session Keynote, International Conference on Machine Learning, Role of Machine Learning in Transforming Healthcare Workshop, Atlanta, GA, June 2013.

Institute of Medicine workshop on Learning Health Care Systems, Washington, DC, April 2013.

Center for Computational Biology and Bioinformatics, IUPUI, Indianapolis, IN, March 2013.

Annual Meeting of the Association of Clinical Pharmacology and Therapeutics, Indianapolis, IN, March 2013.

Living Well Through Data, New York, NY, October 2012.

3rd Annual Pacific Coast Statisticians and Pharmacometricians Innovation Conference, June 2012.

Journal of the American Medical Informatics Association Editor's Choice Journal Club. November 2011.

IBM Healthcare Lecture Series. November 2011.

SFSU Center for Computing for Life Sciences Panel on Data Mining and Predictive Analysis: Research Applications. October 2011.

Popular and Scientific Press

New York Times Magazine, October 2014, Can Big Data Tell Us What Clinical Trials Don’t?, link

Columbia Medicine, June 2014, MiningMedicine Gets Personal, link

New York Times, January 2013, Mining Electronic Health Records for Revealing Health Data, link

Genome Web, December 2012, "Seventh Annual Young Investigators." link

Science Careers, April 2012, "Computational Biologists: The Next Pharma Scientists?" link

In response to Lorberbaum, et al. JAMIA (2016)

Chicago Tribue, October 10, 2016, "Scientists see progress in identifying deadly drug interactions." link

Live Science, October 10, 2016, "Deadly Mixture: Scientists Uncover Harmful Drug Interactions." link

Cardiology Today, October 20, 2016, "Data mining, lab testing approach reveals ceftriaxone-lansoprazole interaction" link

In response to Boland, et al. JAMIA (2015)

TIME, June 2015, "See What Diseases You're at Risk For Based on Your Birth Month." link

The Washington Post, June 2015, "Scientists have discovered how the month you're born matters for your health." link

CBS News, June 2015, "Could your birth month indicate your risk of disease?" link

Discover, June 2015, "Your Birth Month Influences Your Risk for Diseases." link

and >200 others.

In response to Tatonetti, et al. Science Transl Med (2012)

Communications of the ACM, October 2012, "Digging for Drug Facts." link

Nature, March 2012, "Drug data reveal sneaky side effects." link

Gizmodo, March 2012, "Drugs Cause About Five Times More Side Effects Than We Realized." link

GenomeWeb, March 2012, "Good Apart, Bad Together." link

ABC News SLC, March 2012, "Drugs may cause five times more side effects than previously believed." link

In response to Tatonetti, et al. Clinical Pharm & Therap (2011)

DrugTopics, August 2011, "Data-mining uncovers hyperglycemic drug-drug interaction between paroxetine and pravastatin." link

Journal of the American Medical Association, July 2011, "Data Mining Approach Shows Promise in Detecting Unexpected Drug Interactions." link

NewScientist, May 2011, "Common drug combo increases diabetes risk." link

US News, May 25, 2011, "Combo of Paxil, Pravachol May Raise Blood Sugar." link

NPR Shots Health Blog, May 25, 2011, "How A MacBook Pro Found Unexpected Drug Side Effects." link

Selected Awards and Honors

Mentor for the NIH and NSF 2018 Data Science Innovation Lab, 2018

New Investigator Award, American Medical Informatics Association (AMIA), November 2016

Irving Scholars Award, Irving Institute for Clinical and Translational Research ($180,000), July 2015

Kavli Foundational Fellow, May 2014

PhRMA Foundation Early Career Award ($100,000), January 2014

Featured by Genome Web in the Seventh Annual Young Investigator Profiles, December 2012

Highlighted Research in the IMIA Yearbook of Medical Informatics, 2012

Top Podium Presentation Award - AMIA Summit on Translational Bioinformatics, March 2011

Best Presentation (Runner Up) - Biomedical Computation at Stanford, November 2010

Outstanding Paper Award - AMIA Summit on Translational Bioinformatics, March 2010

Department of Energy Graduate Fellowship ($150,000), September 2010

National Library of Medicine Training Grant Recipient, September 2008

Phi Beta Kappa Lifetime Member, November 2007

Beckman Scholar Award ($17,600), May 2007 - October 2008

Goldwater Scholar Honorable Mention, April 2007

ASU SOLUR Researcher Award, August 2006 - May 2007

1997 Pinto Horse Association of America National Champion, All Around-Year End Youth High Point Award

1997 Pinto Horse Association of America National Youth Reining Horse Champion

Teaching Experience

Instructor, Translational Bioinformatics (BINF G4006), Columbia University, Fall 2015, Fall 2016, Fall 2017, Fall 2019

Instructor, Introduction to Biomedical Informatics, Columbia University, 2014-2019

Director, Biomedical Informatics Research Seminar, Columbia University, 2013-2014

Guest Lecturer, Medical Genetics, Columbia University, December 2013

Guest Lecturer, Introduction to Biomedical Informatics, Columbia University, December 2012, November 2013

Teaching Assistant for Course Design, Methods in Healthcare Informatics (BIOMEDIN215), Stanford University, March 2011

Teaching Assistant, Genomics and Personalized Medicine (GENE210), Stanford University, March 2011 - June 2011

Guest Lecturer, Statistical Genetics (GENE244), Stanford University, February 2011

Teaching Assistant, Representations and Algorithms for Computational Molecular Biology (BIOMEDIN214), Stanford University, March 2010 - June 2010

Teaching Assistant, Modeling biomedical systems: ontology, terminology, problem solving (BIOMEDIN210), Stanford University, September 2009 - December 2009

Related and Professional Experience

Partner, Woven Sciences, LLC, 2020-Present

Scientific Advisory Board Member, Gilead/Goldfinch Collaboration, 2020-Present

Scientific Advisor, Advera Health, 2012-Present

Scientific Advisor, You Gene, Inc., New York City, NY 2013-2019

Chief Executive Officer, Stimulomics, Inc., Portola Valley, CA 2009-2012

Chief Science Officer, Mophilia, Inc., Mountain View, CA 2009-2010

Chief Technical Officier (volunteer), The Triple Helix, Inc., Ithica, NY 2006-2007

Vice President/Co-Founder (volunteer), The Triple Helix at ASU, Tempe, AZ 2006

Founder/Owner, Tatonetti Web_Construction, Tempe, AZ 2003 - 2008